The truth is, you can't escape CGT, even if you work from home.
Here's what's included in CGT if you work from home
The Practical Tax Loose Leaf Service explains that if you use a portion of your residence for business purposes, this portion won't form part of a primary residence. Any gains or losses made on this portion must be included for CGT purposes.
This means that if you claim expenses for your office or study at home, that portion of your property will be subject to CGT when you dispose of the property.
The onus is on you to declare all your gains and losses, to calculate your due taxes correctly and to pay SARS on time.